Bipolar Disorder (BD) is a debilitating condition that affects many individuals and their families. It is not just a mental health issue, but a public health problem due to its prevalence, chronic nature, and comorbidities with other medical conditions. This is where BIPCOM comes in, with a precision medicine approach targeting three objectives: identifying risk factors, conducting clinical studies, and developing a Clinical Support Tool (CST) to improve personalized treatment outcomes. The final product will encompass a series of recommendations that aid in individualized clinical decision-making for BD comorbidity management. This will improve prevention, early detection, and effective treatment while assuring the translation of project results into clinical practice. BIPCOM will be implemented via ongoing consultations with stakeholders such as scientific and patient associations, users, and families, to ensure the acceptability and transferability of the findings. The project’s successful implementation will significantly impact the overall health of individuals with BD, potentially resulting in lower mortality rates and reduced incidence of severe disabilities, while also providing dependable techniques and tools for personalized care.